Eigene Publikationen des ZpGA-Teams

  • Wolf, D., Fischer, F. U., Riedel, D., Knaepen, K., Kollmann, B., Kocabayoglu, M., Brüggen, K., Teipel, S., Tüscher, O., Binder, H., Mierau, A., & Fellgiebel, A. (2020). The Impact of Age on the Association Between Physical Activity and White Matter Integrity in Cognitively Healthy Older Adults [Brief Research Report]. Frontiers in Aging Neuroscience, 12. doi.org/10.3389/fnagi.2020.579470
  • Wolf, D., Fischer, F. U., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative (2019). Impact of Resilience on the Association Between Amyloid-β and Longitudinal Cognitive Decline in Cognitively Healthy Older Adults. Journal of Alzheimer's disease: JAD, 70(2), 361–370. https://doi.org/10.3233/JAD-190370
  • Fischer, F. U., Wolf, D., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative. (2019). Connectivity and morphology of hubs of the cerebral structural connectome are associated with brain resilience in AD- and age-related pathology. Brain Imaging and Behavior, 13(6), 1650–1664. https://doi.org/10.1007/s11682-019-00090-y
  • Wolf, D., Fischer, F. U., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative (2019). A methodological approach to studying resilience mechanisms: demonstration of utility in age and Alzheimer's disease-related brain pathology. Brain Imaging and Behavior, 13(1), 162–171. https://doi.org/10.1007/s11682-018-9870-8
  • Wolf, D., Tüscher, O., Teipel, S. et al. Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study. Trials 19, 337 (2018). doi.org/10.1186/s13063-018-2688-2
  • Wolf, D., Rhein, C., Geschke, K., & Fellgiebel, A. (2019). Preventable hospitalizations among older patients with cognitive impairments and dementia. International Psychogeriatrics, 31(3), 383–391. doi.org/10.1017/S1041610218000960
  • Linnemann, A., Hilsenbek, M. M., Lelieveld, I., Geschke, K., Wolf, D., & Fellgiebel, A. (2020). Comparison of psychosocial and medical characteristics of patients with dementia and their primary informal caregivers between inpatient and day clinic treatment. Dementia (London, England), 19(3), 606–617. doi.org/10.1177/1471301218781130
  • Wolf, D. (2017). Hirnstrukturelle und funktionelle Bildgebung. In Fellgiebel A., Hautzinger M. (Hrsg.) Altersdepression: Ein interdisziplinäres Handbuch (1.Aufl., S. 43-48). Springer, Berlin, Heidelberg. doi.org/10.1007/978-3-662-53697-1
  • Wolf, D., Bocchetta, M., Preboske, G. M., Boccardi, M., Grothe, M. J., & Alzheimer's Disease Neuroimaging Initiative (2017). Reference standard space hippocampus labels according to the European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative harmonized protocol: Utility in automated volumetry. Alzheimer's & Dementia : The Journal of the Alzheimer's Association, 13(8), 893–902. https://doi.org/10.1016/j.jalz.2017.01.009
  • Fischer, F. U., Wolf, D., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative (2017). Diaschisis-Like Association of Hippocampal Atrophy and Posterior Cingulate Cortex Hypometabolism in Cognitively Normal Elderly Depends on Impaired Integrity of Parahippocampal Cingulum Fibers. Journal of Alzheimer's Disease : JAD, 60(4), 1285–1294. doi.org/10.3233/JAD-170147
  • Schuck, F., Wolf, D., Fellgiebel, A., & Endres, K. (2016). Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging. Journal of Alzheimer's Disease: JAD, 50(3), 817–826. https://doi.org/10.3233/JAD-150737
  • Wolf, D., Fischer, F. U., de Flores, R., Chételat, G., & Fellgiebel, A. (2015). Differential associations of age with Vol. and microstructure of hippocampal subfields in healthy older adults. Human Brain Mapping, 36(10), 3819–3831. https://doi.org/10.1002/hbm.22880
  • Wolf, D., Fischer, F. U., Scheurich, A., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative (2015). Non-Linear Association between Cerebral Amyloid Deposition and White Matter Microstructure in Cognitively Healthy Older Adults. Journal of Alzheimer's Disease: JAD, 47(1), 117–127. doi.org/10.3233/JAD-150049
  • Fischer, F. U., Wolf, D., Scheurich, A., Fellgiebel, A., & Alzheimer's Disease Neuroimaging Initiative (2015). Altered whole-brain white matter networks in preclinical Alzheimer's disease. NeuroImage: Clinical, 8, 660–666. doi.org/10.1016/j.nicl.2015.06.007
  • Boccardi, M., Bocchetta, M., Morency, F. C., Collins, D. L., Nishikawa, M., Ganzola, R., Grothe, M. J., Wolf, D., Redolfi, A., Pievani, M., Antelmi, L., Fellgiebel, A., Matsuda, H., Teipel, S., Duchesne, S., Jack, C. R., & Frisoni, G. B. (2015). Training labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol. Alzheimer's and Dementia, 11(2), 175-183. https://doi.org/10.1016/j.jalz.2014.12.002
  • Duchesne, S., Valdivia, F., Robitaille, N., Mouiha, A., Valdivia, F. A., Bocchetta, M., Apostolova, L. G., Ganzola, R., Preboske, G., Wolf, D., Boccardi, M., Jack, C. R., Jr, Frisoni, G. B., & EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative (2015). Manual segmentation qualification platform for the EADC-ADNI harmonized protocol for hippocampal segmentation project. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 11(2), 161–174. doi.org/10.1016/j.jalz.2015.01.002
  • Wolf, D., Grothe, M., Fischer, F. U., Heinsen, H., Kilimann, I., Teipel, S., & Fellgiebel, A. (2014). Association of basal forebrain volumes and cognition in normal aging. Neuropsychologia, 53, 54–63. doi.org/10.1016/j.neuropsychologia.2013.11.002
  • Wolf, D., Fischer, F. U., Fesenbeckh, J., Yakushev, I., Lelieveld, I. M., Scheurich, A., Schermuly, I., Zschutschke, L., & Fellgiebel, A. (2014). Structural integrity of the corpus callosum predicts long-term transfer of fluid intelligence-related training gains in normal aging. Human Brain Mapping, 35(1), 309–318. doi.org/10.1002/hbm.22177
  • Wolf, D., Zschutschke, L., Scheurich, A., Schmitz, F., Lieb, K., Tüscher, O., & Fellgiebel, A. (2014). Age-related increases in Stroop interference: delineation of general slowing based on behavioral and white matter analyses. Human Brain Mapping, 35(5), 2448–2458. doi.org/10.1002/hbm.22340
  • Fischer, F. U., Wolf, D., Scheurich, A., & Fellgiebel, A. (2014). Association of structural global brain network properties with intelligence in normal aging. PloS one, 9(1), e86258. https://doi.org/10.1371/journal.pone.0086258
  • Bocchetta, M., Boccardi, M., Ganzola, R., Apostolova, L. G., Preboske, G., Wolf, D., Ferrari, C., Pasqualetti, P., Robitaille, N., Duchesne, S., Jack, C. R., Jr, Frisoni, G. B., & EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative (2015). Harmonized benchmark labels of the hippocampus on magnetic resonance: the EADC-ADNI project. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 11(2), 151–60.e5. doi.org/10.1016/j.jalz.2013.12.019
  • Frisoni, G. B., Jack, C. R., Jr, Bocchetta, M., Bauer, C., Frederiksen, K. S., Liu, Y., Preboske, G., Swihart, T., Blair, M., Cavedo, E., Grothe, M. J., Lanfredi, M., Martinez, O., Nishikawa, M., Portegies, M., Stoub, T., Ward, C., Apostolova, L. G., Ganzola, R., Wolf, D., … EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative (2015). The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 11(2), 111–125. doi.org/10.1016/j.jalz.2014.05.1756
  • Fellgiebel, A., Wolf, D. O., Kolodny, E., & Müller, M. J. (2012). Hippocampal atrophy as a surrogate of neuronal involvement in Fabry disease. Journal of Inherited Metabolic Disease, 35(2), 363–367. https://doi.org/10.1007/s10545-011-9390-9
  • Schermuly, I., Wolf, D., Lieb, K., Stoeter, P., & Fellgiebel, A. (2011). State dependent posterior hippocampal volume increases in patients with major depressive disorder. Journal of Affective Disorders, 135(1-3), 405–409. doi.org/10.1016/j.jad.2011.07.017
  • Wuttke, D.A., Upadhyay, A., Siemsen, E., Wuttke-Linnemann, A. (2022). Seeing the Bigger Pic-ture? Ramping Up Production with the Use of Augmented Reality. Manufacturing & Service Operations Management.
  • Wuttke-Linnemann, A., Palm, S., Geschke, K., Skoluda, N., Nater, U.M., Endres, K., Fellgiebel, A. (in press). Biopsychological evaluation of the feasibility of day clinic treatment for people living with dementia. Frontiers in Ageing Neuroscience.
  • Wuttke-Linnemann, A., Henrici, C., Skoluda, N., Nater, U.M., Endres, K., Fellgiebel, A. (2022). Psychobiological monitoring of a home-based dyadic intervention for people with dementia and their caregivers – added value to evaluate treatment success and understand underlying mechanisms. Journal of Alzheimer’s Disease. 10.3233/JAD-210618. Advance online publication.
  • Wuttke-Linnemann, A., Scholz, L., Fellgiebel, A. (2021). Introduction and Psychometric Validation oft the Resilience and Strain Questionnaire (ResQ-Care) – A Scale on the Ration of Informal Caregivers‘ Resilience and Stress Factors. Frontiers in Psychiatry, 12:778633.
  • Sittler, M.C., Worschech, F., Wilz, G., Fellgiebel, A., Wuttke-Linnemann, A. (2021). Psychobiological mechanisms underlying the health-beneficial effects of music in people living with dementia: A systematic review of the literature. Physiology and Behavior.
  • Geschke, K.*, Palm, S.*, Fellgiebel, A., Wuttke-Linnemann, A. (2021). Resilience in informal caregivers of people living with dementia in the face of COVID-19 pandemic-related changes in daily life – a narrative review. GeroPsych. *shared first authorship
  • Geschke, K., Wuttke-Linnemann, A., Fellgiebel, A. (2020). Pflegende Angehörige im Fokus. Neurotransmitter. 7-8/2020.
  • Wuttke-Linnemann, A., Henrici, C. B., Müller, N., Lieb, K., & Fellgiebel, A. (2020). Bouncing back from the burden of dementia: Predictors of resilience from the perspective of the patient, the spousal caregiver, and the dyad—An exploratory study. GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry, 33(3), 170.
  • Geschke, K., Wuttke-Linnemann, A., Fellgiebel, A. (2020). Pflegende Angehörige im Fokus. Neurotransmitter. 7-8/2020.
  • Fancourt, D., Geschke, K., Fellgiebel, A., Wuttke-Linnemann, A. (2020). Life-time musical training and cognitive performance in memory clinic patients. Musicae Scientiae.
  • Wuttke-Linnemann, A., Feneberg, A., Nater, U.M. (2020), Music and Health. Encyclopedia of Behavioral Medicine. Springer: New York.
  • Wuttke-Linnemann A., Halsband C. A. & Fellgiebel, A. (2020). Fragebogen zur Angehörigen-Resilienz und -Belastung bei Demenz (FARBE)- DEM. Berlin: Zentrum für Qualität in der Pflege (ZQP).
  • Wuttke-Linnemann, A., Baake, R., Fellgiebel, A. (2019). Dyadic wind of change: New approaches to improve biopsychological stress regulation in patients with dementia and their spousal caregivers. Journal of Alzheimer’s Disease. 68(4), 1325-1337.
  • Wuttke-Linnemann, A. (2022). Psychotherapeutischer Umgang mit psychotischen Symptomen bei Menschen mit Demenz. Psychotherapie im Alter, 19(2), 183-196.
  • Wangler, J., Geschke, K., Wuttke-Linnemann, A., Fellgiebel, A., Jansky, M. (2022). Prävention von demenzbedingten Versorgungskrisen im hausarztbasierten Setting – das Projekt DemStepCare als innovative Versorgungsform. Prävention und Gesundheitsförderung.
  • Romero, B., & Geschke, K. (2021) Selbst bei Demenz: Verluste, individuelle Anpassungsmechanismen und psychosoziale Unterstützungsmöglichkeiten. Psychotherapie im Alter. In press.
  • Geschke, K., Wangler, J., Wuttke-Linnemann, A., Jansky, M., & Fellgiebel, A. (2020). Unterstützung für Hausärzte und Betroffene: Optimierte ambulante Demenzversorgung im Rheinland-Pfälzischen Innovationsfonds-Projekt DemStepCare. Zeitschrift für Allgemeinmedizin. 97(3), 120-124.
  • Geschke, K.*, Palm, S.*, Fellgiebel, A., Wuttke-Linnemann, A. (2021). Resilience in informal caregivers of people living with dementia in the face of COVID-19 pandemic-related changes in daily life – a narrative review. GeroPsych. *shared first authorship
  • Geschke, K. (2020). Klinische Versorgung des Delirs. InFo Neurologie & Psychiatrie, 22(10), 46-52.
  • Geschke, K., Wuttke-Linnemann, A., & Fellgiebel, A. (2020). Pflegende Angehörige im Fokus. NeuroTransmitter, 31(7-8), 28-31.
  • Geschke, K., Weyer-Elberich, V., Binder, H., & Fellgiebel, A. (2020). Screening for Cognitive Impairment in Hospitalized Older Patients. The Journal of Gerontopsychology and Geriatric Psychiatry. Online first. doi: 10.1024/1662-9647/a000253
  • Fancourt, D., Geschke, K., Fellgiebel, A., & Wuttke-Linnemann, A. (2020). Lifetime Musical Training and Cognitive Performance in a Memory Clinic Population: A Cross-Sectional Study. Musicae Scientiae. Online first. doi: 10.1177/1029864920918636
  • Ludolph, P., Stoffers-Winterling, J., Kunzler, A. M., Rösch, R., Geschke, K., Vahl, C. F., & Lieb, K. (2020). Non-Pharmacologic Multicomponent Interventions Preventing Delirium in Hospitalized People. Journal of the American Geriatrics Society, 68(8), 1864–1871.
  • Linnemann, A., Hilsenbek, M. M., Lelieveld, I., Geschke, K., Wolf, D., & Fellgiebel, A. (2020). Comparison of psychosocial and medical characteristics of patients with dementia and their primary informal caregivers between inpatient and day clinic treatment. Dementia, 19(3), 606-617.
  • Geschke, K., Weyer‐Elberich, V., Mueller, A. K., Binder, H., & Fellgiebel, A. (2019). Feasibility and utility of a cognitive screening for risk stratification in hospitalized older patients. International Journal of Geriatric Psychiatry, 34(4), 588-593.
  • Wolf, D., Rhein, C., Geschke, K., & Fellgiebel, A. (2019). Preventable hospitalizations among older patients with cognitive impairments and dementia. International Psychogeriatrics, 31(3), 383-391.
  • Romero, B., & Geschke, K. (2019). Selbsterhaltungstherapie für Menschen mit Demenz. InFo Neurologie & Psychiatrie, 21(3), 28-33.
  • Linnemann, A. und Fellgiebel, A. (2017). Psychotherapie bei leichter kognitiver Beeinträchtigung und Demenz. Der Nervenarzt. doi.org/10.1007/s00115-017-0408-x
  • Hefner, G., Geschke, K., & Hiemke, C. (2014). Severe adverse drug events under combination of nortriptyline and melperone due to pharmacokinetic interaction. Journal of clinical psychopharmacology, 34(3), 394–396.
  • Geschke, K., Fellgiebel, A., Laux, N., Schermuly, I., & Scheurich, A. (2013). Quality of life in dementia: impact of cognition and insight on applicability of the SF-36. The American Journal of Geriatric Psychiatry, 21(7), 646-654.
  • Geschke, K., Scheurich, A., Schermuly, I., Laux, N., Böttcher, A., & Fellgiebel, A. (2012). Hausarztbasierte Demenzversorgung: Effektivität früher psychosozialer Beratung der Angehörigen. DMW-Deutsche Medizinische Wochenschrift, 137(43), 2201-2206.
  • Fischer, F. U., Wolf, D., Tüscher, O., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative. (2021). Structural Network Efficiency Predicts Resilience to Cognitive Decline in Elderly at Risk for Alzheimer’s Disease. Frontiers in Aging Neuroscience, 13, 44.
  • Wolf, D., Fischer, F. U., Riedel, D., Knaepen, K., Kollmann, B., Kocabayoglu, M., ... & Fellgiebel, A. (2020). The impact of age on the association between physical activity and white matter integrity in cognitively healthy older adults. Frontiers in Aging Neuroscience, 12.
  • Fischer, Florian U., Wolf, D., Fellgiebel, A. "Connectivity and morphology of hubs of the cerebral structural connectome are associated with brain resilience in AD-and age-related pathology." Brain imaging and behavior 13.6 (2019): 1650-1664.
  • Wolf, D., Fischer, F. U., & Fellgiebel, A. (2019). A methodological approach to studying resilience mechanisms: demonstration of utility in age and Alzheimer’s disease-related brain pathology. Brain imaging and behavior, 13(1), 162-171.
  • Wolf, D., Fischer, F. U., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative. (2019). Impact of Resilience on the Association Between Amyloid-β and Longitudinal Cognitive Decline in Cognitively Healthy Older Adults. Journal of Alzheimer's Disease, 70(2), 361-370.
  • Wolf, D., Tüscher, O., Teipel, S., Mierau, A., Strüder, H., Drzezga, A., ... & Fellgiebel, A. (2018). Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study. Trials, 19(1), 1-15.
  • Fischer, F. U., Wolf, D., & Fellgiebel, A. (2017). Diaschisis-Like Association of Hippocampal Atrophy and Posterior Cingulate Cortex Hypometabolism in Cognitively Normal Elderly Depends on Impaired Integrity of Parahippocampal Cingulum Fibers. Journal of Alzheimer's Disease, 60(4), 1285-1294.
  • Fischer, F. U., Wolf, D., Scheurich, A., Fellgiebel, A., & Alzheimer's Disease Neuroimaging Initiative. (2015). Altered whole-brain white matter networks in preclinical Alzheimer's disease. NeuroImage: clinical, 8, 660-666.
  • Wolf, D., Fischer, F. U., de Flores, R., Chételat, G., & Fellgiebel, A. (2015). Differential associations of age with volume and microstructure of hippocampal subfields in healthy older adults. Human brain mapping, 36(10), 3819-3831.
  • Wolf, D., Fischer, F. U., Scheurich, A., & Fellgiebel, A. (2015). Non-linear association between cerebral amyloid deposition and white matter microstructure in cognitively healthy older adults. Journal of Alzheimer's Disease, 47(1), 117-127.
  • Zou, N., Chetelat, G., Baydogan, M. G., Li, J., Fischer, F. U., Titov, D., ... & Yakushev, I. (2015). Metabolic connectivity as index of verbal working memory. Journal of Cerebral Blood Flow & Metabolism, 35(7), 1122-1126.
  • Fischer, F. U., Wolf, D., Scheurich, A., & Fellgiebel, A. (2014). Association of structural global brain network properties with intelligence in normal aging. PloS one, 9(1), e86258.
  • Wolf, D., Fischer, F. U., Fesenbeckh, J., Yakushev, I., Lelieveld, I. M., Scheurich, A., ... & Fellgiebel, A. (2014). Structural integrity of the corpus callosum predicts long‐term transfer of fluid intelligence‐related training gains in normal aging. Human brain mapping, 35(1), 309-318.
  • Yakushev, I., Chételat, G., Fischer, F. U., Landeau, B., Bastin, C., Scheurich, A., ... & Salmon, E. (2013). Metabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults. Neuroimage, 79, 184-190.
  • Fischer, F. U., Scheurich, A., Wegrzyn, M., Schermuly, I., Bokde, A. L., Klöppel, S., ... & Fellgiebel, A. (2012). Automated tractography of the cingulate bundle in Alzheimer's disease: a multicenter DTI study. Journal of Magnetic Resonance Imaging, 36(1), 84-91.
  • Yakushev, I., Chetelat, G., Fischer, F., Landeau, B., Bastin, C., Scheurich, A., ... & Fellgiebel, A. (2012). Connectivity within the default mode network relates to working memory performance in young healthy subjects. Journal of Nuclear Medicine, 53(supplement 1), 304-304.

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Depression im Alter - Eine Informationsbroschüre für Betroffene, Angehörige und alle Interessierten

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Ärzteblatt RLP 9/23
Quelle: LÄK RLP/ M. Hempel/A. Semar; Illustration: Adobe Stock/xartproduction (bearbeitet)

Ärzteblatt Rheinland-Pfalz 9/23 - Schwerpunkt: Demenz - Wenn das Gedächtnis Lücken bekommt

  • Resilienz und Stressbelastung pflegender Angehöriger von Menschen mit Demenz
    Dr. Katharina Geschke Oberärztin, Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Mainz Zentrum für psychische Gesundheit im Alter (ZpGA) Mainz, Landeskrankenhaus (AöR)
    Prof. Dr. Alexandra Wuttke Junior-Professorin, Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie, Zentrum für psychische Gesundheit, Universitätsklinikum Würzburg Leiterin des Zentrums für psychische Gesundheit im Alter (ZpGA) Mainz, Landeskrankenhaus (AöR)
  • Prävention und kognitive Resilienz bei Demenz
    Prof. Dr. Andreas Fellgiebel Leiter Zentrum für psychische Gesundheit im Alter Landeskrankenhaus (AöR) Mainz, Chefarzt, Klinik für Psychiatrie, Psychosomatik und Psychotherapie Agaplesion Elisabethenstift Darmstadt

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